From GlobeNewswire: 2025-05-17 10:40:00

Tectonic Therapeutic announced positive results from Phase 1b trial of TX45 in patients with Group 2 Pulmonary Hypertension in Heart Failure with preserved Ejection Fraction (PH-HFpEF). The data confirmed the drug’s tolerability and improvements in left ventricular function and pulmonary hemodynamics, showing sustained effects for 29 days. TX45 demonstrated a reduction in pulmonary capillary wedge pressure and pulmonary vascular resistance, correlating with improved exercise capacity and mortality. The drug also improved hemodynamics in patients with different ranges of left ventricular ejection fractions. The results support the potential of TX45 as a treatment for PH-HFpEF patients. Tectonic’s new data confirms TX45’s positive effects on patients with Group 2 Pulmonary Hypertension in Heart Failure with preserved Ejection Fraction (PH-HFpEF), showing improvements in left ventricular function and pulmonary hemodynamics. TX45 was found to sustain these benefits for 29 days, across different left ventricular ejection fractions. This study is significant as there are currently no approved medications for this condition. TX45 is a long-acting Fc-relaxin fusion protein that activates the RXFP1 receptor and has shown promising results in improving cardiopulmonary hemodynamics. The clinical trial design includes both Part A and Part B, with enrollment ongoing and data expected in the second half of 2025. TX45 has been shown to be well-tolerated and effective in improving left ventricular function and pulmonary hemodynamics in patients with Group 2 Pulmonary Hypertension in Heart Failure with preserved Ejection Fraction (PH-HFpEF). A new echocardiographic analysis revealed sustained hemodynamic effects for up to 29 days after TX45 treatment. The drug also demonstrated improvements in cardiac and pulmonary hemodynamics in PH-HFpEF patients with varying left ventricular ejection fractions, including those with LVEF≥50% and LVEF 41-49%.



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