In 2025, small-cap stocks underperformed, with the Russell 2000 Index delivering a total return of around 13%, significantly lower than the S&P 500’s 18% return. Despite this, three small-cap stocks saw exceptional growth, including GRAIL (NASDAQ: GRAL), which rose by approximately 380% due to its Galleri Multi-Cancer Early Detection test.

GRAIL’s early cancer detection technology, detecting over 50 types of cancer, led to a 380% stock increase in 2025. The company plans to apply for FDA approval in 2026, potentially unlocking new sales channels. Analysts are optimistic, with a consensus price target of $97.50 indicating a 14% upside.

Planet Labs PBC (NYSE: PL) experienced a massive 2025 with shares rising nearly 390%. The satellite company focuses on providing data and images of Earth to aid decision-making. Strong demand, particularly from governments, led to a 35% increase in shares after an earnings report. Analysts have a mixed outlook, with a consensus price target implying a 25% downside, but updated targets suggesting a 7.7% downside.

Viasat (NASDAQ: VSAT) gained approximately 305% in 2025, reaching a market cap of around $4.7 billion. The satellite company specializes in internet and data connectivity for aviation, maritime, and government customers. While the consensus price target implies a 5% downside, updated targets post-earnings report indicate a potential 37% upside.

Overall, these small-cap stocks had impressive performances in 2025, but investors should be cautious due to the risks associated with smaller stocks experiencing significant gains. Due diligence is crucial to understanding their long-term potential amidst potential volatility.

Read more at Yahoo Finance: These 3 Stocks Rose Over 300% in 2025